On January 6, 2021, a South Carolina senator sponsoring medical cannabis legislation discussed plans to pass the bill in 2021. This indicates ongoing efforts to legalize medical marijuana in the state, with the senator expressing intention to move the legislation forward in the coming year. The push for medical cannabis legalization in South Carolina represents a significant development in the state's approach to marijuana policy.

In December 2020, Republican lawmakers in South Carolina announced their intention to legalize medical cannabis by prefiling several bills. Additionally, newly introduced legislation aimed to legalize recreational marijuana, decriminalize possession, and place the decision on the ballot for voters to decide.

Rep.-elect Nancy Mace (R-SC) expresses her support for legalizing marijuana and has appointed a new staff member who previously served as the chief operating officer for the Cannabis Trade Federation.